購(gòu)物車(chē)
幫助
021-54845833/15800441009
概述
|
Fusion protein corresponding to a region derived from 686-985 amino acids of human AARS2 |
技術(shù)規(guī)格
|
Full name: |
Alanyl-tRNA synthetase 2, mitochondrial |
|
Synonyms: |
AARSL; COXPD8; MTALARS; MT-ALARS |
|
Swissprot: |
Q5JTZ9 |
|
Gene Accession: |
BC131728 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
|
Expression system: |
Escherichia coli |
|
Tags: |
His tag C-Terminus, GST tag N-Terminus |
|
Background: |
The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. Aminoacyl-tRNA synthetases play critical roles in mRNA translation by charging tRNAs with their cognate amino acids. The encoded protein is a mitochondrial enzyme that specifically aminoacylates alanyl-tRNA. Mutations in this gene are a cause of combined oxidative phosphorylation deficiency 8. Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain |
