Background:
This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms.
Applications:
ELISA, WB
Name of antibody:
HTRA2
Immunogen:
Synthetic peptide of human HTRA2
Full name:
HtrA serine peptidase 2
Synonyms:
OMI; MGCA8; PARK13; PRSS25
SwissProt:
O43464
ELISA Recommended dilution:
5000-10000
WB Predicted band size:
49 kDa
WB Positive control:
Rat brain tissue, Mouse brain tissue, Raji and 231 cell lysates
WB Recommended dilution:
500-2000
技術規格