Name: ZYX 抗原（重組蛋白）
Brand: 通蔚生物

中文名稱： ZYX 抗原（重組蛋白）

英文名稱： ZYX Antigen (Recombinant Protein)

別名： zyxin; ESP-2; HED-2

相關類別：抗原

儲存：冷凍（-20℃）

概述

Fusion protein corresponding to a region derived from 373-572 amino acids of human ZYX

技術規格

Full name:	zyxin
Synonyms:	ESP-2; HED-2
Swissprot:	Q15942
Gene Accession:	BC008743
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform.

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