購(gòu)物車(chē)
幫助
021-54845833/15800441009
中文名稱(chēng)：小鼠抗CRK單克隆抗體
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Background: |
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. |
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Applications: |
WB |
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Name of antibody: |
CRK |
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Immunogen: |
Fusion protein of human CRK |
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Full name: |
CRK proto-oncogene, adaptor protein |
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Synonyms: |
p38; CRKII |
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SwissProt: |
P46108 |
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WB Predicted band size: |
34 kDa |
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WB Positive control: |
Lncap, A431, MCF7 and HT1080 cell lysates |
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WB Recommended dilution: |
1000-5000 |
