中文名稱: UBR7 抗原(重組蛋白)
英文名稱: UBR7 Antigen (Recombinant Protein)
別 名: ubiquitin protein ligase E3 component n-recognin 7 (putative); C14orf130
相關類別:抗原
儲 存: 冷凍(-20℃)
概 述
技術規格
Full name: |
ubiquitin protein ligase E3 component n-recognin 7 (putative) |
Synonyms: |
C14orf130 |
Swissprot: |
Q8N806 |
Gene Accession: |
BC015046 |
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
Expression system: |
Escherichia coli |
Tags: |
His tag C-Terminus, GST tag N-Terminus |
Background: |
Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). Ubr7 (ubiquitin protein ligase E3 component n-recognin 7), also known as C14orf130 or N-recognin-7, is a 425 amino acid protein that contains one UBR-type zinc finger and one PHD zinc finger. Participating in protein modification events within the N-end rule pathway, Ubr7 functions as an E3 ubiquitin-protein ligase that recognizes and binds proteins that contain destabilizing N-terminal residues, thereby leading to their ubiquitination and subsequent degradation. |