購(gòu)物車
幫助
021-54845833/15800441009
中文名稱： UBE2D1 抗原（重組蛋白）
英文名稱： UBE2D1 Antigen (Recombinant Protein)
別 名： ubiquitin conjugating enzyme E2 D1; SFT; UBCH5; UBC4/5; UBCH5A; E2(17)KB1
相關(guān)類別：抗原
儲(chǔ) 存： 冷凍（-20℃）
概 述
|
Full name: |
ubiquitin conjugating enzyme E2 D1 |
|
Synonyms: |
SFT; UBCH5; UBC4/5; UBCH5A; E2(17)KB1 |
|
Swissprot: |
P51668 |
|
Gene Accession: |
BC005980 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
|
Expression system: |
Escherichia coli |
|
Tags: |
His tag C-Terminus, GST tag N-Terminus |
|
Background: |
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. Two transcript variants encoding different isoforms have been found for this gene. |
