中文名稱: TAB3 抗原(重組蛋白)
英文名稱: TAB3 Antigen (Recombinant Protein)
別 名: TGF-beta activated kinase 1/MAP3K7 binding protein 3; NAP1; MAP3K7IP3
儲 存: 冷凍(-20℃)
相關類別:抗原
概 述
技術規格
Full name: |
TGF-beta activated kinase 1/MAP3K7 binding protein 3 |
Synonyms: |
NAP1; MAP3K7IP3 |
Swissprot: |
Q8N5C8 |
Gene Accession: |
BC032526 |
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
Expression system: |
Escherichia coli |
Tags: |
His tag C-Terminus, GST tag N-Terminus |
Background: |
The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. |