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中文名稱：兔抗CCND2(Ab-280)多克隆抗體
英文名稱： Anti-CCND2(Ab-280) rabbit polyclonal antibody
別 名： MPPH3; KIAK0002
相關(guān)類別： 一抗
儲(chǔ) 存： 冷凍（-20℃） 避光
抗 原： CCND2(Ab-280)
宿 主： Rabbit
反應(yīng)種屬： Human
標(biāo) 記 物： Unconjugate
克隆類型： rabbit polyclonal
技術(shù)規(guī)格
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Background: |
Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex By similarity. |
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Applications: |
WB |
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Name of antibody: |
CCND2(Ab-280) |
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Immunogen: |
Synthesized non-phosphopeptide derived from human Cyclin D2 around the phosphorylation site of threonine 280 (A-S-T(p)-P-T). |
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Full name: |
cyclin D2 |
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Synonyms： |
MPPH3; KIAK0002 |
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SwissProt: |
P30279 |
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WB Predicted band size: |
33 kDa |
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WB Positive control: |
293 cells lysate |
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WB Recommended dilution: |
500-3000 |
