購(gòu)物車
幫助
021-54845833/15800441009
中文名稱：兔抗WWTR1多克隆抗體
英文名稱： Anti-WWTR1 rabbit polyclonal antibody
別 名： WW domain containing transcription regulator 1; TAZ
抗 原 : WWTR1
相關(guān)類別： 一抗
儲(chǔ) 存： 冷凍（-20℃）
宿 主： Rabbit
反應(yīng)種屬： Human, Mouse
標(biāo) 記 物： Unconjugate
克隆類型： rabbit polyclonal
技術(shù)規(guī)格
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Background: |
The transcriptional co-activator with PDZ-binding motif (TAZ) is a 14-3-3-binding molecule. The highly conserved and ubiquitously expressed 14-3-3 proteins regulate differentiation, cell cycle progression and apoptosis by binding intracellular phosphoproteins involved in signal transduction. TAZ may link events at the plasma membrane and cytosketeton to nuclear transcription in a manner that can be regulated by 14-3-3. TAZ shares homology with the WW domain of Yes-associated protein (YAP) and functions as a transcriptional co-activator by binding to the PPXY motif present on transcription factors. TAZ recognizes immunoreactive protein bands in lysates from MDCK, NIH-3T3 and 293T cells. In addition, COS7, Hep G2, CHO and HeLa cells express endogenous TAZ. 14-3-3 binding requires TAZ phosphorylation on a single Serine 89 residue, resulting in the inhibition of TAZ transcriptional co-activation through 14-3-3-mediated nuclear export. |
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Applications: |
ELISA, WB |
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Name of antibody: |
WWTR1 |
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Immunogen: |
Synthetic peptide of human WWTR1 |
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Full name: |
WW domain containing transcription regulator 1 |
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Synonyms: |
TAZ |
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SwissProt: |
Q9GZV5 |
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ELISA Recommended dilution: |
5000-10000 |
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WB Predicted band size: |
44 kDa |
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WB Positive control: |
HEPG2, Jurkat, A431 and NIH/3T3 cell lysates |
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WB Recommended dilution: |
200-1000 |
