Background: |
The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene. |
Applications: |
ELISA, IHC |
Name of antibody: |
TGFBR1 |
Immunogen: |
Synthetic peptide of human TGFBR1 |
Full name: |
transforming growth factor, beta receptor 1 |
Synonyms: |
AAT5; ALK5; MSSE; SKR4; ALK-5; LDS1A; LDS2A; TGFR-1; ACVRLK4 |
SwissProt: |
P36897 |
IHC positive control: |
Human gastric cancer |
IHC Recommend dilution: |
100-300 |