Background: |
This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. |
Applications: |
WB |
Name of antibody: |
TEK(Phospho-Tyr992) |
Immunogen: |
Peptide sequence around phosphorylation site of tyrosine 992 (E-V-Y(p)-V-K) derived from Human TIE2. |
Full name: |
TEK tyrosine kinase, endothelial |
Synonyms: |
TIE2; VMCM; TIE-2; VMCM1; CD202B |
SwissProt: |
Q02763 |
WB Predicted band size: |
126 kDa |
WB Positive control: |
HepG2 cells lysates |
WB Recommended dilution: |
500-1000 |