Background: |
Endocytosis of cell surface proteins is mediated by a complex molecular machinery that assembles on the inner surface of the plasma membrane. This gene encodes one of two human homologs of the Drosophila melanogaster stoned B protein. This protein is related to components of the endocytic machinery and exhibits a modular structure consisting of an N-terminal proline-rich domain, a central region of homology specific to the human stoned B-like proteins, and a C-terminal region homologous to the mu subunits of adaptor protein (AP) complexes. Read-through transcription of this gene into the neighboring downstream gene, which encodes TFIIA-alpha/beta-like factor, generates a transcript (SALF), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. Alternative splicing results in multiple transcript variants. |
Applications: |
WB |
Name of antibody: |
STON1 |
Immunogen: |
Synthesized peptide derived from C-terminal of human STON1. |
Full name: |
stonin 1 |
Synonyms: |
SALF; SBLF; STN1; STNB1 |
SwissProt: |
Q9Y6Q2 |
WB Predicted band size: |
83 kDa |
WB Positive control: |
K562 cells lysate |
WB Recommended dilution: |
500-3000 |