Background:
The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described.
Applications:
IHC, IF
Name of antibody:
GRIN1(Phospho-Ser890)
Immunogen:
Peptide sequence around phosphorylation site of Serine 890(A-S-S(p)-F-K) derived from Human NMDAR1.
Full name:
glutamate receptor, ionotropic, N-methyl D-aspartate 1
Synonyms:
NR1; MRD8; GluN1; NMDA1; NMDAR1
SwissProt:
Q05586
IHC positive control:
Human brain tissue
IHC Recommend dilution:
50-100
IF positive control:
A549 cells
IF Recommend dilution:
100-200