購物車
幫助
021-54845833/15800441009
中文名稱： 兔抗PRKAA2多克隆抗體
英文名稱： Anti-PRKAA2 rabbit polyclonal antibody
別 名： AMPK; AMPK2; PRKAA; AMPKa2
相關(guān)類別： 一抗
儲(chǔ) 存： 冷凍（-20℃）
抗 原： PRKAA2
宿 主： Rabbit
反應(yīng)種屬： Human, Mouse, Rat
標(biāo) 記 物： Unconjugate
克隆類型： rabbit polyclonal
技術(shù)規(guī)格
|
Background: |
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. |
|
Applications: |
ELISA, IHC |
|
Name of antibody: |
PRKAA2 |
|
Immunogen: |
Fusion protein of human PRKAA2 |
|
Full name: |
protein kinase, AMP-activated, alpha 2 catalytic subunit |
|
Synonyms： |
AMPK; AMPK2; PRKAA; AMPKa2 |
|
SwissProt: |
P54646 |
|
ELISA Recommended dilution: |
2000-5000 |
|
IHC positive control: |
Human liver cancer and human thyroid cancer |
|
IHC Recommend dilution: |
25-100 |
