中文名稱: 兔抗PPP4R2多克隆抗體
英文名稱: Anti-PPP4R2 rabbit polyclonal antibody
別 名: PP4R2
相關類別: 一抗
儲 存: 冷凍(-20℃) 避光
宿 主: Rabbit
抗 原: PPP4R2
反應種屬: Human Mouse
標 記 物: Unconjugate
克隆類型: rabbit polyclonal
技術規格
Background: |
Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair. |
Applications: |
WB |
Name of antibody: |
PPP4R2 |
Immunogen: |
Synthesized peptide derived from internal of human PP4R2. |
Full name: |
protein phosphatase 4, regulatory subunit 2 |
Synonyms: |
PP4R2 |
SwissProt: |
Q9NY27 |
WB Predicted band size: |
47 kDa |
WB Positive control: |
K562 cells and COS7 cells lysates |
WB Recommended dilution: |
500-3000 |