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021-54845833/15800441009
中文名稱： 兔抗PPP2R2B多克隆抗體
英文名稱： Anti-PPP2R2B rabbit polyclonal antibody
別 名： PR52B; SCA12; B55BETA; PR55BETA; PP2ABBETA; PP2APR55B; PR2ABBETA; PR55-BETA; PP2AB55BETA; PR2AB55BETA;PP2APR55BETA; PR2APR55BETA
相關(guān)類別： 一抗
儲 存： 冷凍（-20℃） 避光
宿 主： Rabbit
抗 原： PPP2R2B
反應種屬： Human Mouse Rat
標 記 物： Unconjugate
克隆類型： rabbit polyclonal
技術(shù)規(guī)格
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Background: |
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in this gene cause autosomal dominant spinocerebellar ataxia 12 (SCA12), a disease caused by degeneration of the cerebellum, sometimes involving the brainstem and spinal cord, and in resulting in poor coordination of speech and body movements. Multiple alternatively spliced variants, which encode different isoforms, have been identified for this gene. The 5' UTR of some of these variants includes a CAG trinucleotide repeat sequence (7-28 copies) that can be expanded to 66-78 copies in cases of SCA12. |
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Applications: |
WB |
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Name of antibody: |
PPP2R2B |
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Immunogen: |
Synthesized peptide derived from internal of human PPP2R2B. |
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Full name: |
protein phosphatase 2, regulatory subunit B, beta |
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Synonyms： |
PR52B; SCA12; B55BETA; PR55BETA; PP2ABBETA; PP2APR55B; PR2ABBETA; PR55-BETA; PP2AB55BETA; PR2AB55BETA; PP2APR55BETA; PR2APR55BETA |
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SwissProt: |
Q00005 |
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WB Predicted band size: |
56 kDa |
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WB Positive control: |
Hela cells lysate |
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WB Recommended dilution: |
500-3000 |
