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  • 兔抗PPM1D多克隆抗體

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    • 品牌 : 通蔚生物
    • 目錄號 : TW21864
    • 應用 : 僅供科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現(xiàn)貨
    • 商品庫存:80
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中文名稱:  兔抗PPM1D多克隆抗體


英文名稱:  Anti-PPM1D rabbit polyclonal antibody


別       名:  protein phosphatase, Mg2+/Mn2+ dependent 1D WIP1; PP2C-DELTA


抗       原:  PPM1D


儲      存:  冷凍(-20℃)


宿      主:  Rabbit


相關(guān)類別:  一抗


反應種屬  Human, Mouse


標  記  物:  Unconjugate


克隆類型:  rabbit polyclonal


技術(shù)規(guī)格

Background:

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.

Applications:

ELISA, WB, IHC

Name of antibody:

PPM1D

Immunogen:

Fusion protein of human PPM1D

Full name:

protein phosphatase, Mg2+/Mn2+ dependent 1D

Synonyms:

WIP1; PP2C-DELTA

SwissProt:

O15297

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human liver cancer and Human esophagus cancer

IHC Recommend dilution:

40-200

WB Predicted band size:

67 kDa

WB Positive control:

Human placenta tissue lysate

WB Recommended dilution:

200-1000









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