Background: |
This gene encodes a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme beta-hexosaminidase A. Beta-hexosaminidase A, together with GM2 ganglioside activator, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in this gene result in GM2-gangliosidosis type AB or the AB variant of Tay-Sachs disease. Alternative splicing results in multiple transcript variants. |
Applications: |
ELISA, WB, IHC |
Name of antibody: |
GM2A |
Immunogen: |
Fusion protein of human GM2A |
Full name: |
GM2 ganglioside activator |
Synonyms: |
SAP-3; GM2-AP |
SwissProt: |
P17900 |
ELISA Recommended dilution: |
5000-10000 |
IHC positive control: |
Human lung cancer |
IHC Recommend dilution: |
20-100 |
WB Predicted band size: |
21 kDa |
WB Positive control: |
Human 2-3 grade bladder transitional cell carcinoma tissue, Mouse kidney tissue, Hela cell, 293T cell, A375 cell |
WB Recommended dilution: |
200-1000 |