購(gòu)物車(chē)
幫助
021-54845833/15800441009
中文名稱(chēng)： 兔抗RIPK1多克隆抗體
英文名稱(chēng)： Anti-RIPK1 rabbit polyclonal antibody
別 名： RIP; RIP1; RIP-1
抗 原： RIPK1
儲(chǔ) 存： 冷凍（-20℃）
宿 主： Rabbit
相關(guān)類(lèi)別： 一抗
反應(yīng)種屬： Human
標(biāo) 記 物： Unconjugate
克隆類(lèi)型： rabbit polyclonal
技術(shù)規(guī)格
|
Background: |
Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex. |
|
Applications: |
ELISA, WB |
|
Name of antibody: |
RIPK1 |
|
Immunogen: |
Fusion protein of human RIPK1 |
|
Full name: |
receptor interacting serine/threonine kinase 1 |
|
Synonyms: |
RIP; RIP1; RIP-1 |
|
SwissProt: |
Q13546 |
|
ELISA Recommended dilution: |
5000-10000 |
|
WB Predicted band size: |
76 kDa |
|
WB Positive control: |
HEPG2,Hela and K562 cell lysates |
|
WB Recommended dilution: |
500-2000 |
