Background: |
Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Finally, peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia. |
Applications: |
ELISA, IHC |
Name of antibody: |
F2 |
Immunogen: |
Synthetic peptide of humanF2 |
Full name: |
coagulation factor II (thrombin) |
Synonyms: |
PT; THPH1; RPRGL2 |
SwissProt: |
P00734 |
ELISA Recommended dilution: |
2000-5000 |
IHC positive control: |
Human thyroid cancer and Human prostate cancer |
IHC Recommend dilution: |
25-100 |