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  • ERH抗原(重組蛋白)

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    • 品牌 : 通蔚生物
    • 目錄號 : TW18628
    • 應(yīng)用 : 僅供科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現(xiàn)貨
    • 商品庫存:90
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中文名稱:ERH抗原(重組蛋白)

英文名稱: ERH Antigen (Recombinant Protein)

別      名: DROER

儲      存: 冷凍(-20℃)

相關(guān)類別: 抗原

概      述:

Fusion protein corresponding to a region derived from 1-104 amino acids of human ERH


技術(shù)規(guī)格:

Full name:

ERH, mRNA splicing and mitosis factor

Synonyms:

DROER

Swissprot:

P84090

Gene Accession:

BC014301

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

ERH (enhancer of rudimentary homolog), also known as DROER, is a 104 amino acid transcriptional coregulator that is ubiquitously expressed and highly conserved among eukaryotes. ERH may play a role in cell cycle regulation and pyrimidine biosynthesis. ERH represses the function of the coactivator PCBD, preventing it from enhancing the activity of the tissue-specific transcription factor HNF-1 (hepatocyte nuclear factor-1). HNF-1 is a homeodomain transcription factor that binds DNA as a dimer and the HNF-1/DNA complex is stabilized by PCBD. By repressing PCBD, ERH disrupts the stability of the HNF-1/DNA complex, affecting the expression of multiple genes in the liver. The structure of ERH is characterized by a single domain consisting of three alpha-helices and four beta-strands. ERH has a long flexible loop that is significantly conserved, suggesting that this loop region may be important for the function of ERH. ERH has two casein kinase II phosphorylation sites that are thought to disrupt the ability of ERH to dimerize.


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