中文名稱:SETMAR抗原(重組蛋白)
英文名稱: SETMAR Antigen (Recombinant Protein)
別 名: Mar1; METNASE
儲(chǔ) 存: 冷凍(-20℃)
相關(guān)類別: 抗原
概 述:
Fusion protein corresponding to a region derived from 14-213 amino acids of human SETMAR |
Full name: |
SET domain and mariner transposase fusion gene |
Synonyms: |
Mar1; METNASE |
Swissprot: |
Q53H47 |
Gene Accession: |
BC011635 |
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
Expression system: |
Escherichia coli |
Tags: |
His tag C-Terminus, GST tag N-Terminus |
Background: |
This gene encodes a fusion protein that contains an N-terminal histone-lysine N-methyltransferase domain and a C-terminal mariner transposase domain. The encoded protein binds DNA and functions in DNA repair activities including non-homologous end joining and double strand break repair. The SET domain portion of this protein specifically methylates histone H3 lysines 4 and 36. This gene exists as a fusion gene only in anthropoid primates, other organisms lack mariner transposase domain. Alternate splicing results in multiple transcript variants. |