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  • INPP5D 抗原(重組蛋白)

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    • 品牌 : 通蔚生物
    • 目錄號(hào) : TW17993
    • 應(yīng)用 : 僅供科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現(xiàn)貨
    • 商品庫(kù)存:90
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中文名稱(chēng):  INPP5D 抗原(重組蛋白)

英文名稱(chēng): INPP5D Antigen (Recombinant Protein)

別      名: inositol polyphosphate-5-phosphatase D; SHIP; SHIP1; SHIP-1; hp51CN; SIP-145; p150Ship

儲(chǔ)      存: 冷凍(-20℃)

相關(guān)類(lèi)別: 抗原

概述

Fusion protein corresponding to a region derived from 1001-1189 amino acids of human INPP5D


技術(shù)規(guī)格

Full name:

inositol polyphosphate-5-phosphatase D

Synonyms:

SHIP; SHIP1; SHIP-1; hp51CN; SIP-145; p150Ship

Swissprot:

Q92835

Gene Accession:

BC113580

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants.


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