購物車
幫助
021-54845833/15800441009
中文名稱： INAVA 抗原（重組蛋白）
英文名稱： INAVA Antigen (Recombinant Protein)
別 名： innate immunity activator; C1orf106
相關類別： 抗原
概述
|
Fusion protein corresponding to a region derived from 464-663 amino acids of human INAVA |
|
Full name: |
innate immunity activator |
|
Synonyms: |
C1orf106 |
|
Swissprot: |
Q3KP66 |
|
Gene Accession: |
BC106877 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
|
Expression system: |
Escherichia coli |
|
Tags: |
His tag C-Terminus, GST tag N-Terminus |
|
Background: |
Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion (PubMed:28436939). In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation (PubMed:29420262). |
