中文名稱:ILK抗原(重組蛋白)
英文名稱: ILK Antigen (Recombinant Protein)
別 名: P59; ILK-1; ILK-2; p59ILK
儲(chǔ) 存: 冷凍(-20℃)
相關(guān)類別: 抗原
概述
Fusion protein corresponding to a region derived from 193-446 amino acids of human ILK |
Full name: |
integrin-linked kinase |
Synonyms: |
P59; ILK-1; ILK-2; p59ILK |
Swissprot: |
Q13418 |
Gene Accession: |
BC001554 |
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
Expression system: |
Escherichia coli |
Tags: |
His tag C-Terminus, GST tag N-Terminus |
Background: |
This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. |