中文名稱:IL1R2抗原(重組蛋白)
英文名稱: IL1R2 Antigen (Recombinant Protein)
儲 存: 冷凍(-20℃)
相關類別: 抗原
概述
Fusion protein corresponding to a region derived from 25-239 amino acids of human IL1R2 |
Full name: |
Interleukin-1 receptor type 2 |
Synonyms: |
IL1RB, CD121b, CDw121b, IL-1R-2, IL-1RT2, IL-1RT-2 |
Swissprot: |
P27930 |
Gene Accession: |
BC039031 |
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
Expression system: |
Escherichia coli |
Tags: |
His tag C-Terminus, GST tag N-Terminus |
Background: |
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. |