Name: VWA5A抗原（重組蛋白）
Brand: 通蔚生物

中文名稱：VWA5A抗原（重組蛋白）

英文名稱： VWA5A Antigen (Recombinant Protein)

別名： BCSC1; BCSC-1; LOH11CR2A

儲存： 冷凍（-20℃）

相關類別：抗原

概述：

Fusion protein corresponding to C terminal 250 amino acids of human VWA5A

技術規格：

Full name:	von Willebrand factor A domain containing 5A
Synonyms:	BCSC1; BCSC-1; LOH11CR2A
Swissprot:	O00534
Gene Accession:	BC001234
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	VWA5A (von Willebrand factor A domain containing 5A), also known as BCSC-1 (breast cancer suppressor candidate 1) or LOH11CR2A (loss of heterozygosity 11 chromosomal region 2 gene A protein), is a 786 amino acid protein containing one VIT domain and one VWFA domain. VWA5A is expressed at low levels in various tissues, with no expression found in 80% of tumor cell lines. Likely acting as a tumor suppressor gene, deletion of VWA5A leads to loss of heterozygosity (LOH) in breast and ovarian tumors, and may have an important role as a potential gene therapy target. Abnormal expression of VWA5A may lead to an increase in adhesion of CNE-2L2 cells associated with an increase in expression of E-cadherin, alpha-catenin, and p53, resulting in a decrease of malignant activity in cells with ectopic expression of VWA5A.

展開全部

欧美一级免费-欧美一级免费观看-欧美一级免费看-欧美一级免费片-jizzjizz大全-jizzjizz国产精品

ELISA試劑盒