Name: PSMD8抗原（重組蛋白）
Brand: 通蔚生物

中文名稱： PSMD8抗原（重組蛋白）

英文名稱： PSMD8 Antigen (Recombinant Protein)

別名： S14, p31, HIP6, HYPF, Nin1p, Rpn12

儲存： 冷凍（-20℃）

相關類別：抗原

概述

Fusion protein corresponding to a region derived from 94-350 amino acids of human PSMD8

技術規格

Full name:	proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
Synonyms:	S14, p31, HIP6, HYPF, Nin1p, Rpn12
Swissprot:	P48556
Gene Accession:	BC001164
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 1.

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