中文名稱: DLD抗原(重組蛋白)
英文名稱: DLD Antigen (Recombinant Protein)
別 名: E3; LAD; DLDD; DLDH; GCSL; PHE3
相關類別: 抗原
概 述:
Fusion protein corresponding to C terminal 250 amino acids of human DLD |
Full name: |
dihydrolipoamide dehydrogenase |
Synonyms: |
E3; LAD; DLDD; DLDH; GCSL; PHE3 |
Swissprot: |
P09622 |
Gene Accession: |
BC018696 |
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
Expression system: |
Escherichia coli |
Tags: |
His tag C-Terminus, GST tag N-Terminus |
Background: |
This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In homodimeric form, the encoded protein functions as a dehydrogenase and is found in several multi-enzyme complexes that regulate energy metabolism. However, as a monomer, this protein can function as a protease. Mutations in this gene have been identified in patients with E3-deficient maple syrup urine disease and lipoamide dehydrogenase deficiency. Alternative splicing results in multiple transcript variants. |