Name: PC抗原（重組蛋白）
Brand: 通蔚生物

中文名稱： PC抗原（重組蛋白）

英文名稱： PC Antigen (Recombinant Protein)

別名： PCB

儲存： 冷凍（-20℃）

相關類別：抗原

概述

Fusion protein corresponding to a region derived from 563-832 amino acids of human PC

技術規格

Full name:	Pyruvate carboxylase
Synonyms:	PCB
Swissprot:	P11498
Gene Accession:	BC011617
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene.

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