Name: NR0B2抗原（重組蛋白）
Brand: 通蔚生物

中文名稱： NR0B2抗原（重組蛋白）

英文名稱： NR0B2 Antigen (Recombinant Protein)

別名： SHP; SHP1

儲存： 冷凍（-20℃）

相關(guān)類別：抗原

概述

Fusion protein corresponding to a region derived from 57-228 amino acids of human NR0B2

技術(shù)規(guī)格

Full name:	nuclear receptor subfamily 0 group B member 2
Synonyms:	SHP; SHP1
Swissprot:	Q15466
Gene Accession:	BC030207
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.

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