Full name: |
NME/NM23 family member 7 |
Synonyms: |
NDK7; NDK 7; MN23H7; nm23-H7 |
Swissprot: |
Q9Y5B8 |
Gene Accession: |
BC006983 |
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
Expression system: |
Escherichia coli |
Tags: |
His tag C-Terminus, GST tag N-Terminus |
Background: |
nm23-H7, also known as NME7 (non-metastatic cells 7), is a 376 amino acid protein that contains one DM10 domain and belongs to the NDK family. Using magnesium as a cofactor, nm23-H7 functions to catalyze the ATP-dependent creation of nucleoside triphosphates, thereby playing an essential role in metabolic pathways throughout the body. The gene encoding nm23-H7 maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma. |