中文名稱:CERK抗原(重組蛋白)
英文名稱: CERK Antigen (Recombinant Protein)
別 名: LK4; hCERK; dA59H18.2; dA59H18.3
儲 存: 冷凍(-20℃)
相關類別: 抗原
概 述:
Fusion protein corresponding to a region derived from 128-278 amino acids of human CERK |
Full name: |
ceramide kinase |
Synonyms: |
LK4; hCERK; dA59H18.2; dA59H18.3 |
Swissprot: |
Q8TCT0 |
Gene Accession: |
BC126940 |
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
Expression system: |
Escherichia coli |
Tags: |
His tag C-Terminus, GST tag N-Terminus |
Background: |
CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated in various cellular processes, including proliferation, apoptosis, phagocytosis, and inflammation. Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Binds phosphoinositides. |