Name: CARF 抗原（重組蛋白）
Brand: 通蔚生物

中文名稱：CARF 抗原（重組蛋白）

英文名稱： CARF Antigen (Recombinant Protein)

別名： calcium responsive transcription factor; ALS2CR8; NYD-SP24

儲存： 冷凍（-20℃）

相關類別： 抗原

概述：

Fusion protein corresponding to C terminal 300 amino acids of human CARF

技術規格：

Full name:	calcium responsive transcription factor
Synonyms:	ALS2CR8; NYD-SP24
Swissprot:	Q8N187
Gene Accession:	BC033777
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	CARF (calcium-response factor), also known as ALS2CR8 (amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein) or NYD-SP24, is a 725 amino acid nuclear protein. Expressed in a wide variety of tissues with highest expression in the hippocampus, CARF is thought to be a transcription factor that associates with the p53 tumor suppression pathway. CARF cooperates, co-localizes and is co-regulated with ARF, an ADP-ribosylation factor, and, through this interaction, helps to mediate ARF-p53-induced apoptotic signaling. This apoptotic pathway is implicated in cell cycle control, proper cellular development, response to DNA damage and the aging process, suggesting that CARF participates in various events throughout the cell.

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