Name: MSH4抗原（重組蛋白）
Brand: 通蔚生物

中文名稱： MSH4抗原（重組蛋白）

英文名稱： MSH4 Antigen (Recombinant Protein)

儲存： 冷凍（-20℃）

相關類別：抗原

概述

Fusion protein corresponding to a region derived from C terminal 300 amino acids of human MSH4

技術規格

Full name:	mutS homolog 4
Swissprot:	O15457
Gene Accession:	BC033030
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	This gene encodes a member of the DNA mismatch repair mutS family. This member is a meiosis-specific protein that is not involved in DNA mismatch correction, but is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis I. This protein and MSH5 form a heterodimer which binds uniquely to a Holliday Junction and its developmental progenitor, thus provoking ADP-ATP exchange, and stabilizing the interaction between parental chromosomes during meiosis double-stranded break repair.

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