中文名稱:BMI1抗原(重組蛋白)
英文名稱: BMI1 Antigen (Recombinant Protein)
別 名: PCGF4; RNF51; FLVI2/BMI1
儲 存: 冷凍(-20℃)
相關類別: 抗原
概 述:
Fusion protein corresponding to N terminal 250 amino acids of human BMI1 |
Full name: |
BMI1 polycomb ring finger oncogene |
Synonyms: |
PCGF4; RNF51; FLVI2/BMI1 |
Swissprot: |
P35226 |
Gene Accession: |
BC011652 |
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
Expression system: |
Escherichia coli |
Tags: |
His tag C-Terminus, GST tag N-Terminus |
Background: |
BMI1 polycomb ring finger oncogene, also known as BMI1, is a protein which in humans is encoded by the BMI1gene. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2. |