購物車
幫助
021-54845833/15800441009
中文名稱：ASCC1抗原（重組蛋白）
英文名稱： ASCC1 Antigen (Recombinant Protein)
別 名： p50; CGI-18; ASC1p50
儲 存： 冷凍（-20℃）
相關類別： 抗原
概 述：
|
Fusion protein corresponding to C terminal 250 amino acids of human ASCC1 |
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Full name: |
activating signal cointegrator 1 complex subunit 1 |
|
Synonyms: |
p50; CGI-18; ASC1p50 |
|
Swissprot: |
Q8N9N2 |
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Gene Accession: |
BC012291 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. |
