Name: COPS5抗原（重組蛋白）
Brand: 通蔚生物

中文名稱： COPS5抗原（重組蛋白）

英文名稱： COPS5 Antigen (Recombinant Protein)

別名： CSN5, JAB1, SGN5, MOV-34

儲存： 冷凍（-20℃）

相關類別：抗原

概述

Fusion protein corresponding to a region derived from 1-334 amino acids of human COPS5

技術規格

Full name:	COP9 constitutive photomorphogenic homolog subunit 5
Synonyms:	CSN5, JAB1, SGN5, MOV-34
Swissprot:	Q92905
Gene Accession:	BC001187
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors

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