中文名稱: APIP 抗原(重組蛋白)
別 名: APAF1 interacting protein; APIP2, CGI29, CGI-29, MMRP19, dJ179L10.2
Full name: |
APAF1 interacting protein |
Synonyms: |
APIP2, CGI29, CGI-29, MMRP19, dJ179L10.2 |
Swissprot: |
Q96GX9 |
Gene Accession: |
BC008440 |
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
Expression system: |
Escherichia coli |
Tags: |
His tag C-Terminus, GST tag N-Terminus |
Background: |
APIP is an APAF1 (MIM 602233)-interacting protein that acts as a negative regulator of ischemic/hypoxic injury.The protein highly expressed in skeletal muscle and heart and binds to the CARD of Apaf-1 in competition with caspase-9. Exogenous APIP inhibits cytochrome c-induced activation of caspase-3 and caspase-9, and suppresses cell death triggered by mitochondrial apoptotic stimuli through inhibiting the downstream activity of cytochrome c released from mitochondria. |