中文名稱:ACVR1抗原(重組蛋白)
英文名稱: ACVR1 Antigen (Recombinant Protein)
別 名: FOP; ALK2; SKR1; TSRI; ACTRI; ACVR1A; ACVRLK2
儲 存: 冷凍(-20℃)
相關類別: 抗原
概 述:
Fusion protein corresponding to a region derived from 260-509 amino acids of human ACVR1 |
技術規格:
Full name: |
activin A receptor type I |
Synonyms: |
FOP; ALK2; SKR1; TSRI; ACTRI; ACVR1A; ACVRLK2 |
Swissprot: |
Q04771 |
Gene Accession: |
BC033867 |
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
Expression system: |
Escherichia coli |
Tags: |
His tag C-Terminus, GST tag N-Terminus |
Background: |
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. |