Background: |
The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The encoded protein downregulates the innate immune response and therefore provides a therapeutic target for enhancing its antimicrobial activity against foreign agents. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and X. |
Applications: |
ELISA, IHC |
Name of antibody: |
CNOT7 |
Immunogen: |
Fusion protein of human CNOT7 |
Full name: |
CCR4-NOT transcription complex subunit 7 |
Synonyms: |
CAF1; CAF-1; Caf1a; hCAF-1 |
SwissProt: |
Q9UIV1 |
ELISA Recommended dilution: |
5000-10000 |
IHC positive control: |
Human lung cancer |
IHC Recommend dilution: |
50-100 |