英文名稱: Anti-PPM1D mouse monoclonal antibody
抗 原: PPM1D
克隆類型: mouse monoclonal
技術規格
Background: |
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. |
Applications: |
WB |
Name of antibody: |
PPM1D |
Immunogen: |
Fusion protein of human PPM1D |
Full name: |
protein phosphatase, Mg2+/Mn2+ dependent 1D |
Synonyms: |
WIP1; IDDGIP; PP2C-DELTA |
SwissProt: |
O15297 |
WB Predicted band size: |
67 KD |
WB Positive control: |
Jurkat, HEK293, Hela cell lysates |
WB Recommended dilution: |
500-2000 |