Fusion protein corresponding to C terminal 300 amino acids of human HSPH1 |
技術規(guī)格
Full name: |
Heat shock 105kDa/110kDa protein 1 |
Synonyms: |
HSP105; HSP105A; HSP105B; NY-CO-25 |
Swissprot: |
Q92598 |
Gene Accession: |
BC037553 |
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
Expression system: |
Escherichia coli |
Tags: |
His tag C-Terminus, GST tag N-Terminus |
Background: |
Heat shock protein 105 kDa is a protein that in humans is encoded by the HSPH1 gene. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities. Highly expressed in testis. Present at lower levels in most brain regions, except cerebellum. Overexpressed in cancer cells. Phosphorylation on Ser-509 may be important for regulation of the HSPA8/HSC70 chaperone activity. |