中文名稱：HSD3B7 抗原（重組蛋白）

英文名稱：HSD3B7 Antigen (Recombinant Protein)

別名：hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7; CBAS1; PFIC4; SDR11E3

儲存：冷凍（-20℃）

相關類別：抗原

概述

Fusion protein corresponding to N terminal 178 amino acids of human HSD3B7

技術規格

Full name:

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7

Synonyms:

CBAS1; PFIC4; SDR11E3

Swissprot:

Q9H2F3

Gene Accession:

BC004929

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

This gene encodes an enzyme which is involved in the initial stages of the synthesis of bile acids from cholesterol and a member of the short-chain dehydrogenase/reductase superfamily. The encoded protein is a membrane-associated endoplasmic reticulum protein which is active against 7-alpha hydrosylated sterol substrates. Mutations in this gene are associated with a congenital bile acid synthesis defect which leads to neonatal cholestasis, a form of progressive liver disease. Multiple transcript variants encoding different isoforms have been found for this gene.

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HSD3B7 抗原（重組蛋白）說明書
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HSD3B7 抗原（重組蛋白）

Full name:	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
Synonyms:	CBAS1; PFIC4; SDR11E3
Swissprot:	Q9H2F3
Gene Accession:	BC004929
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	This gene encodes an enzyme which is involved in the initial stages of the synthesis of bile acids from cholesterol and a member of the short-chain dehydrogenase/reductase superfamily. The encoded protein is a membrane-associated endoplasmic reticulum protein which is active against 7-alpha hydrosylated sterol substrates. Mutations in this gene are associated with a congenital bile acid synthesis defect which leads to neonatal cholestasis, a form of progressive liver disease. Multiple transcript variants encoding different isoforms have been found for this gene.