Background: |
Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. |
Applications: |
WB |
Name of antibody: |
GAB2(Ab-623) |
Immunogen: |
Synthesized non-phosphopeptide derived from human Gab2 around the phosphorylation site of serine 623 (P-S-S(p)-P-S). |
Full name: |
GRB2-associated binding protein 2 |
Synonyms: |
KIAA0571 |
SwissProt: |
Q9UQC2 |
WB Predicted band size: |
74 kDa |
WB Positive control: |
COS cells lysate |
WB Recommended dilution: |
500-3000 |