別 名: inositol 1,4,5-trisphosphate receptor type 2; ANHD; IP3R2; CFAP48; INSP3R2
技術規格
Background: |
The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production. |
Applications: |
ELISA, IHC |
Name of antibody: |
ITPR2 |
Immunogen: |
Synthetic peptide of human ITPR2 |
Full name: |
inositol 1,4,5-trisphosphate receptor type 2 |
Synonyms: |
ANHD; IP3R2; CFAP48; INSP3R2 |
SwissProt: |
Q14571 |
ELISA Recommended dilution: |
5000-10000 |
IHC positive control: |
Human tonsil and Human esophagus cancer |
IHC Recommend dilution: |
50-300 |