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  • 兔抗NEDD8多克隆抗體

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    • 品牌 : 通蔚生物
    • 目錄號 : TW20681
    • 應(yīng)用 : 僅供科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現(xiàn)貨
    • 商品庫存:80
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中文名稱: 兔抗NEDD8多克隆抗體


英文名稱: Anti-NEDD8 rabbit polyclonal antibody


別       名: NEDD8; FLJ43224; MGC104393; MGC125896; MGC125897; Nedd-8


相關(guān)類別: 一抗


儲       存: 冷凍(-20℃) 避光


宿       主 Rabbit


抗       原: NEDD8


反應(yīng)種屬: Human, Mouse, Rat


標(biāo)  記  物: Unconjugate


克隆類型: rabbit polyclonal


技術(shù)規(guī)格

Background:

Neural precursor cell-expressed developmentally downregulated protein 8 (NEDD8), also known as Rub1 (related to ubiquitin 1) in plants and yeast, is a member of the ubiquitin-like protein family. The covalent attachment of NEDD8 to target proteins, termed neddylation, is a reversible, multi-step process analogous to ubiquitination. NEDD8 is first synthesized in a precursor form with a carboxy-terminal extension peptide that is removed by either the UCH-L3 or NEDP1/DEN1 hydrolase protein to yield a mature NEDD8 protein. Mature NEDD8 is then covalently linked to target proteins via the carboxy-terminal glycine residue in a reaction catalyzed by the APP-BP1/Uba3 heterodimer complex and Ubc12 as the E1- and E2-like enzymes, respectively. An E3 ligase protein, Roc1/Rbx1, is also required for neddylation of the cullin proteins. Protein de-neddylation is catalyzed by a number of enzymes in the cell, including a "ubiquitin-specific" protease USP21, the NEDP1/DEN1 hydrolase and the COP9/signalosome (CSN). In contrast to the ubiquitin pathway, the NEDD8 modification system acts on only a few substrates and does not appear to target proteins for degradation. Neddylation of cullin proteins activates the SCF (Skp1-Cullin-F-box) E3 ubiquitin ligase complex by promoting complex formation and enhancing the recruitment of the E2-ubiquitin intermediate. While NEDD8 modification of VHL is not required for ubiquitination of HIF1-α, it is required for fibronectin matrix assembly. Mdm2-dependent neddylation of p53 inhibits its transcriptional activity.

Applications:

WB

Name of antibody:

NEDD8

Immunogen:

Fusion protein of human NEDD8

Full name:

neural precursor cell expressed, developmentally down-regulated 8

Synonyms:

NEDD8; FLJ43224; MGC104393; MGC125896; MGC125897; Nedd-8

SwissProt:

Q15843

WB Predicted band size:

9 kDa

WB Positive control:

COS1 and Jurkat cells, brain tissue

WB Recommended dilution:

500-2000




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